Synthesis and anti-inflammatory evaluation of novel thiadiazol derivatives of Mefenamic acid

Abstract

In the search for new potential non-steroidal anti-inflammatory agents, some novel Mefenamic acid derivatives were synthesized and confirmed by spectroscopic data. The anti-inflammatory activities of these compounds were evaluated by the croton oil-induced ear oedema test in mice. The preliminary pharmacological evaluations indicate that these new compounds showed potent anti-inflammatory activities compare to control and Indomethacin groups.

KEY WORDS: Non-steroidal anti-inflammatory drugs, Mefenamic acid derivatives, Cyclooxygenase, Ear oedema test

Bull. Chem. Soc. Ethiop. 2017, 31(1), 171-175.

DOI: http://dx.doi.org/10.4314/bcse.v31i1.15