One-pot synthesis of 2,4,5-trisubstituted imidazole derivatives catalyzed by btppc under solvent-free conditions

Abstract

A simple and efficient method for one-pot synthesis of lophine derivatives (2,4,5-trisubstituted imidazoles) by using the benzyltriphenylphosphonium chloride (BTPPC), as a catalyst, under solvent-free conditions is described. BTPPC is an available and inexpensive catalyst; also, it can be easily supplied. This procedure led to the corresponding 2,4,5-trisubstituted imidazoles products in high yields.

KEY WORDS: Lophine derivatives, BTPPC, Solvent-free, One-pot synthesis, Multi component synthesis

Bull. Chem. Soc. Ethiop. 2017, 31(1), 177-184.

DOI: http://dx.doi.org/10.4314/bcse.v31i1.16