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Novel synthesis of pyrazole-containing thiophene, 2-alkyloxy-pyridine and thieno[2,3-d]pyrimidine scaffolds as analgesic agents


N. M. Khalifa
H. H. Fahmy
E. S. Nossier
A. El-Galil E. Amr
R. N. Herqash

Abstract

ABSTRACT. A group of trisubstituted pyrazoles containing thiophen, 2-alkyloxypyridine and thieno[2,3-d]pyrimidine heterocycles were synthesized in a study for possible analgesic agents. The desired products were obtained by reaction of 2-((1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl)methylene)malononitrile with sulfur in presence of TEA, followed by treatment with different reagents. Newer products were examined for their analgesic properties, among them, analog 7 showed significant analgesic effects in comparison with reference medicines activity.

 

KEY WORDS: Trisubstituted pyrazoles, Thiophene, Alkyloxypyridine, Fused pyrimidine, Analgesic activities

 

Bull. Chem. Soc. Ethiop. 2019, 33(3), 505-515. 

DOI: https://dx.doi.org/10.4314/bcse.v33i3.11


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eISSN: 1726-801X
print ISSN: 1011-3924