<b>EFFICIENT SODIUM SELENATE-CATALYZED SYNTHESIS OF 3,4-DIHYDRO-2(1<i>H</i>)-PYRIMIDINONES AND –THIONES UNDER SOLVENT-FREE CONDITIONS</b>

Abstract

Sodium selenate efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a,β-keto ester and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or –thiones in excellent yields.

KEY WORDS: Dihydropyrimidinones, Sodium selenate, Biginelli reaction, Three component reaction


Bull. Chem. Soc. Ethiop. 2009, 23(1), 141-144.