Synthesis and antitubercular activity of 4-oxo-thiazolidine derivatives of 2-amino-5-nitrothiazole

Abstract

New series of N-[3-(2-amino-5-nitrothiazolyl)-propyl]-2-(substituted phenyl)-4-oxo-5-(substituted benzylidene)-1,3-thiazolidine-carboxamide, 5(a-j) have been synthesized from 2-amino-5-nitrothiazole as a starting material. The structure of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR, ¹H NMR, ¹³C NMR and FAB-Mass. All the final synthesized compounds 5(a-j) were screened for their antibacterial and antifungal activities against some selected bacteria and fungi with their MIC values and antitubercular activity screened against M. tuberculosis.

KEY WORDS: Synthesis, 2-Amino-5-nitrothiazole, Thiazolidinone, Antimicrobial, Antitubercular

Bull. Chem. Soc. Ethiop. 2013, 27(2), 249-263.

DOI: http://dx.doi.org/10.4314/bcse.v27i2.10