Synthesis and in vitro antimicrobial evaluation of 5-amino-7-aryl-6-cyano-4H- pyrano[3,2,b]pyrrole derivatives catalyzed by reusable ZrOCl2•8H2O

  • A. Mohammed Hussain
  • S. Sheik Mansoor
  • K. Aswin
  • K. Logaiya
  • S. P.N. Sudhan
Keywords: ZrOCl2•8H2O, Pyranopyrrole, Malononitrile, 3-Hydroxypyrrole, Solvent-free


An efficient synthesis of a new series of 5-amino-7-aryl-6-cyano-4H-pyrano[3,2-b]pyrrole derivatives from the reaction of 3-hydroxypyrrole, malononitrile, and various aromatic aldehydes using ZrOCl2·8H2O, an environmentally friendly catalyst under a thermal solvent-free green procedure is described. This simple protocol offer advantages such as shorter reaction times, simple work-up and excellent yield. The catalyst ZrOCl2·8H2O can be reused. The reusability of the catalyst has been studied for the synthesis of 5-amino-7-aryl-6-cyano-4H-pyrano[3,2-b]pyrrole. All the compounds were screened for their antibacterial and antifungal activity.

KEY WORDS: ZrOCl2·8H2O, Pyranopyrrole, Malononitrile, 3-Hydroxypyrrole, Solvent-free

Bull. Chem. Soc. Ethiop. 2014, 28(1), 91-100.




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eISSN: 1726-801X
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