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Application of various types of alumina and nano-γ-alumina sulfuric acid in the synthesis of α-aminonitriles derivatives: comparative study

A. Teimouri
L. Ghorbanian
A. Moatari


An efficient and green protocol for the synthesis of α-aminonitrile derivatives by one-pot reaction of different aldehydes with amines and trimethylsilyl cyanide has been developed using natural alumina, alumina sulfuric acid (ASA), nano-g-alumina, nano-g-alumina sulfuric acid (nano-g-ASA) under microwave irradiation and solvent-free conditions. The advantages of methods are short reaction times, high yields, milder conditions and easy work up. The catalysts can be recovered for the subsequent reactions and reused without any appreciable loss of efficiency.


KEY WORDS: Nano-g-alumina, Nano-g-alumina sulfuric acid, Green synthesis, Microwave irradiation, α-aminonitriles derivatives


Bull. Chem. Soc. Ethiop. 2014, 28(3), 441-450.