Synthesis, characterization and antibacterial evaluation of some novel derivatives of 2-bromomethyl-benzimidazole

  • A. Ahmadi
Keywords: Benzimidazole, Antibacterial activity, Bromo derivatives, Gram-positive strains, Gram-negative strains

Abstract

In the present study, synthesis, and biological evaluation of some novel derivatives of 2-bromomethyl-benzimidazole were investigated. The structures of the new synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, mass spectrometry and elemental analysis and screened for antimicrobial activity against two Gram-positive strains (Staphylococcus aureus and Bacillus subtilis) and two Gram-negative strains (Escherichia coli and Pseudomonas aeruginosa). Results indicate that new compounds showed moderate to good activity when compared with standard antibiotic Ciprofloxacin and Streptomycin.

 

KEY WORDS: Benzimidazole, Antibacterial activity, Bromo derivatives, Gram-positive strains, Gram-negative strains

 

Bull. Chem. Soc. Ethiop. 2014, 28(3), 451-456.

DOI: http://dx.doi.org/10.4314/bcse.v28i3.14

Published
2014-09-22
Section
Articles

Journal Identifiers


eISSN: 1726-801X
print ISSN: 1011-3924