Synthesis, characterization and anti-inflammatory evaluation of novel derivatives of Trolox with pharmacological alcohol and amines

Abstract

In order to explore the novel anti-inflammatory agents, some novel Trolox derivatives were synthesized and characterized by IR, ¹H-NMR, ¹³C-NMR, mass and elemental analysis. The anti-inflammatory activities of the target compounds were evaluated via the croton oil-induced ear oedema test in Swiss mice. According to screened results, obtained compounds demonstrated considerable anti-inflammatory action.

KEY WORDS: Trolox derivatives, Anti-inflammatory agents, Oxidative stress, Croton oil-induced ear oedema test

Bull. Chem. Soc. Ethiop. 2017, 31(2), 331-335.  

DOI: http://dx.doi.org/10.4314/bcse.v31i2.14