Synthesis, characterization and anti-inflammatory evaluation of novel derivatives of Trolox with pharmacological alcohol and amines
In order to explore the novel anti-inflammatory agents, some novel Trolox derivatives were synthesized and characterized by IR, 1H-NMR, 13C-NMR, mass and elemental analysis. The anti-inflammatory activities of the target compounds were evaluated via the croton oil-induced ear oedema test in Swiss mice. According to screened results, obtained compounds demonstrated considerable anti-inflammatory action.
KEY WORDS: Trolox derivatives, Anti-inflammatory agents, Oxidative stress, Croton oil-induced ear oedema test
Bull. Chem. Soc. Ethiop. 2017, 31(2), 331-335.