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Bulletin of the Chemical Society of Ethiopia

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Synthesis, characterization and anti-inflammatory evaluation of novel derivatives of Trolox with pharmacological alcohol and amines

A. Ahmadi

Abstract


In order to explore the novel anti-inflammatory agents, some novel Trolox derivatives were synthesized and characterized by IR, 1H-NMR, 13C-NMR, mass and elemental analysis. The anti-inflammatory activities of the target compounds were evaluated via the croton oil-induced ear oedema test in Swiss mice. According to screened results, obtained compounds demonstrated considerable anti-inflammatory action.

 

KEY WORDS: Trolox derivatives, Anti-inflammatory agents, Oxidative stress, Croton oil-induced ear oedema test

 

Bull. Chem. Soc. Ethiop. 2017, 31(2), 331-335.  

DOI: http://dx.doi.org/10.4314/bcse.v31i2.14




http://dx.doi.org/10.4314/bcse.v31i2.14
AJOL African Journals Online