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Bulletin of the Chemical Society of Ethiopia

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Synthesis and characterization of functionalized dihydropyrimidinones via one-pot isocyanide-based three-component reaction of N-formyl urea and dialkyl ACETYLENEDICARBOXYLATES

A. Naderi, B. Mohtat

Abstract


The reactive intermediate generated by the addition of alkyl isocyanides to dialkyl acetylenedicarboxylates was trapped by N-formyl urea to produce highly functionalized dihydropyrimidinones in fairly good yields.

               

KEY WORDS: Alkyl isocyanides, Dialkyl acetylenedicarboxylate, N-Formyl urea, Three-component reaction, Dihydropyrimidinones

 

Bull. Chem. Soc. Ethiop. 2017, 31(2), 345-350. 

DOI: http://dx.doi.org/10.4314/bcse.v31i2.16




http://dx.doi.org/10.4314/bcse.v31i2.16
AJOL African Journals Online