A 3D polyhedral metal–organic framework as drug carrier for controllable release

  • E. H. Zhou
  • R. Wang
  • J. Wu
  • S. W. Qiu
  • J. Q. Liu
  • H. R. Zhong
  • H. D. Zeng
  • J. W. Xu
  • J. C. Jin
Keywords: Drug delivery, Release, Porous MOF

Abstract

A new fabrication of {[H3O][Cu6(tpta)3(DMA)4(COO)]∙12H2O∙7DMA} (1) was used as a drug vehicle of 5-fluorouracil (5-FU) for drug delivery. The incorporation of the drug 5-FU into the 1 was around 47.3 wt% per gram of dehydrated 1. Cargo release behavior and material degradation profile were also investigated under different mdeium. 5-FU is released in a highly controlled and progressive manner with 92% of the drug release after 96 h at acidic condition and with 88% after 96 h at PBS. In vitro cytotoxicity assays indicated that the 1 possesses no obvious cytotoxicity. The results provide a new avenue for MOFs to be used as potential drug delivery.

               

KEY WORDS: Drug delivery, Release, Porous MOF

 

Bull. Chem. Soc. Ethiop. 2017, 31(3), 457-463. 

DOI: http://dx.doi.org/10.4314/bcse.v31i3.9

Published
2018-01-19
Section
Articles

Journal Identifiers


eISSN: 1726-801X
print ISSN: 1011-3924