Synthesis and pharmacological screening of new isatin-3-[N2-(benzimidazol-1- acetyl)]hydrazone

Abstract

Twenty new isatin-3-[N²-(benzimidazol-1-acetyl)]hydrazones (IV) were synthesized from ten different isatin-3-[N²–(chloroacetyl)] hydrazones (III) by reacting with benzimidazole and 2-methyl benzimidazole. The intermediates were obtained from isatin hydrazones (II) on condensation with chloroacetyl chloride. These compounds were characterized by IR, ¹H NMR and mass spectra. All the compounds were screened for antimicrobial, antioxidant and cytotoxic activity. Some of the new compounds showed promising antibacterial and antifungal activity.

KEY WORDS: Antibacterial activity, Antifungal activity, Antioxidant activity, Cytotoxic activity, Benzimidazole, Isatin

Bull. Chem. Soc. Ethiop. 2019, 33(2), 321-329. 

DOI: https://dx.doi.org/10.4314/bcse.v33i2.12