Catalytic activity of nickel ferrite nanoparticles in synthesis of 4-aryl benzelidene-2- ((5-fluoro-1H-indol-1-yl)methyl)oxazol-5(4H)-one and its evalute the biological activity

  • T. N. Rao
  • N. K. Rao
  • B. Parvatamma
  • V. K. Devi
  • T. M. Naidu
Keywords: 2-(5-Fluoro-1H-indol-1-yl)acetyl chloride, 2-(2-(5-Fluoro-1H-indol-1-yl)acetoamide) acetic acid, 4-Aryl Benzelidene-2-((5-fluoro-1H-indol-1-yl)methyl)oxazol-5(4H)-one, Anti-oxidant, Anti-microbial activity, Nickel ferrite

Abstract

ABSTRACT. Seven 4-arylbenzelidene-2-((5-fluoro-1H-indol-1-yl)methyl)oxazol-5(4H)-one derivatives were synthesized by the condensation of 2-(2-(5-fluoro-1H-indol-1-yl) acetoamide) acetic acid, substituted aromatic aldehydes with acetic anhydride and sodium acetate in the presence of MgO/Al2O3 under reflux using nickel ferrite nanoparticles. Seven of the compounds are new derivatives. 2-(2-(5-fluoro-1H-indol-1-yl)acetoamide) acetic acid was obtained from 2-(5-fluoro-1H-indol-1-yl)acetyl chloride with lysine in the presence of NaOH and HCl in the ice cold solution. 2-(5-fluoro-1H-indol-1-yl)acetyl chloride can be prepared from 5-fluoro indole with chloroacetyl chloride in triethylamine and dichloromethane. The structures of the compounds were evaluated based on 1H-NMR, 13C-NMR and LC-MS and by elemental analysis. These compounds were screened by anti-oxidant as well as anti-microbial activity.

               

KEY WORDS: 2-(5-Fluoro-1H-indol-1-yl)acetyl chloride, 2-(2-(5-Fluoro-1H-indol-1-yl)acetoamide) acetic acid, 4-Aryl Benzelidene-2-((5-fluoro-1H-indol-1-yl)methyl)oxazol-5(4H)-one, Anti-oxidant, Anti-microbial activity, Nickel ferrite

 

Bull. Chem. Soc. Ethiop. 2019, 33(3), 517-526.  

DOI: https://dx.doi.org/10.4314/bcse.v33i3.12

Published
2019-11-15
Section
Articles

Journal Identifiers


eISSN: 1726-801X
print ISSN: 1011-3924