FeCl3-DMF complex as efficient catalyst for the synthesis of 6-acyl-2(3H)-benzoxazolones and 6-acyl-2(3H)-benzothiazolones

Abstract

ABSTRACT. FeCl₃-DMF complex has been tested on Friedel-Crafts reaction of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone with acid chlorides and anhydrides as acylating agents. In these conditions, the 6-acyl-2(3H)-benzoxazolones and 6-acyl-2(3H)-benzothiazolones were obtained in yields ranging from 52 to 89%. Among the various commonly catalysts; AlCl₃-DMF, ZnCl₂-DMF and PPA, explored in this study, the best conditions using FeCl₃-DMF were found the most convenient one

KEY WORDS: FeCl₃-DMF, AlCl₃-DMF, ZnCl₂-DMF, PPA, 6-Acyl-2(3H)-benzothiazolones, 6-Acyl-2(3H)-benzothiazolones

Bull. Chem. Soc. Ethiop. 2019, 33(3), 579-585. 

DOI: https://dx.doi.org/10.4314/bcse.v33i3.18