Antiplasmodial and larvicidal flavonoids from Derris trifoliata

  • A Yenesew
  • H Twinomuhwezi
  • JM Kabaru
  • HM Akala
  • BT Kiremire
  • M Heydenreich
  • MG Peter
  • FI Eyase
  • NC Waters
  • DS Walsh
Keywords: Derris trifoliata, Leguminosae, Flavanone, (S)-Lupinifolin 4´-methyl ether, Lupinifolin, Antiplasmodial, Rotenoid, Larvicide, Aedes aegypti


From the dichloromethane-methanol (1:1) extract of the seed pods of Derris trifoliata, a new flavanone derivative (S)-lupinifolin 4´-methyl ether was isolated. In addition, the known flavonoids lupinifolin and rotenone were identified. The structures were determined on the basis of spectroscopic evidence. Lupinfolin showed moderate in vitro antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquineresistant)
strains of Plasmodium falciparum. The different parts of this plant showed larvicidal activities against Aedes aegypti and rotenoids were identified as the active principles.

Journal Identifiers

eISSN: 1726-801X
print ISSN: 1011-3924