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Bulletin of the Chemical Society of Ethiopia

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A solvent free and selective method for preparation of triphenylmethyl ethers of alcohols and nucleosides

Negar Zekri, Reza Fareghi Alamdari, Ali Khalafi-Nezhad

Abstract


A very simple and efficient method is described for protection of alcohols and nucleosides with trityl(triphenylmethyl), mono and dimethoxytrityl chlorides in the presence of triethylamine under microwave irradiation. High selectivity was observed for tritylation of 5'-OH function of nucleosides.

 

KEY WORDS: Protection, Trityl chlorides, Microwave irradiation, Nucleosides, Selectivity

 

 

Bull. Chem. Soc. Ethiop. 2010, 24(2), 299-304.



http://dx.doi.org/10.4314/bcse.v24i2.54764
AJOL African Journals Online