A solvent free and selective method for preparation of triphenylmethyl ethers of alcohols and nucleosides

Negar Zekri; Reza Fareghi Alamdari; Ali Khalafi-Nezhad

doi:10.4314/bcse.v24i2.54764

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Published:

May 26, 2010

DOI:

10.4314/bcse.v24i2.54764

Keywords:

Protection Trityl chlorides Microwave irradiation Nucleosides Selectivity

Issue

Vol. 24 No. 2 (2010)

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Articles

Negar Zekri

Department of Chemistry and Chemical Engineering, Faculty of Material and Chemical Engineering, Malek-Ashtar University of Technology (MUT), Lavizan, Tehran, P.O. Box 16765-3454, Iran

Reza Fareghi Alamdari

Department of Chemistry and Chemical Engineering, Faculty of Material and Chemical Engineering, Malek-Ashtar University of Technology (MUT), Lavizan, Tehran, P.O. Box 16765-3454, Iran

Ali Khalafi-Nezhad

Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran

Abstract

A very simple and efficient method is described for protection of alcohols and nucleosides with trityl(triphenylmethyl), mono and dimethoxytrityl chlorides in the presence of triethylamine under microwave irradiation. High selectivity was observed for tritylation of 5'-OH function of nucleosides.

KEY WORDS: Protection, Trityl chlorides, Microwave irradiation, Nucleosides, Selectivity

Bull. Chem. Soc. Ethiop. 2010, 24(2), 299-304.

Bulletin of the Chemical Society of Ethiopia
Journal / Bulletin of the Chemical Society of Ethiopia / Vol. 24 No. 2 (2010) / Articles

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<b>A solvent free and selective method for preparation of triphenylmethyl ethers of alcohols and nucleosides</b>

Negar Zekri

Reza Fareghi Alamdari

Ali Khalafi-Nezhad

Abstract

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Negar Zekri

Reza Fareghi Alamdari

Ali Khalafi-Nezhad

Abstract

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