A solvent free and selective method for preparation of triphenylmethyl ethers of alcohols and nucleosides

  • Negar Zekri Department of Chemistry and Chemical Engineering, Faculty of Material and Chemical Engineering, Malek-Ashtar University of Technology (MUT), Lavizan, Tehran, P.O. Box 16765-3454, Iran
  • Reza Fareghi Alamdari Department of Chemistry and Chemical Engineering, Faculty of Material and Chemical Engineering, Malek-Ashtar University of Technology (MUT), Lavizan, Tehran, P.O. Box 16765-3454, Iran
  • Ali Khalafi-Nezhad Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran
DOI: 10.4314/bcse.v24i2.54764
Keywords: Protection, Trityl chlorides, Microwave irradiation, Nucleosides, Selectivity

Abstract

A very simple and efficient method is described for protection of alcohols and nucleosides with trityl(triphenylmethyl), mono and dimethoxytrityl chlorides in the presence of triethylamine under microwave irradiation. High selectivity was observed for tritylation of 5'-OH function of nucleosides.

 

KEY WORDS: Protection, Trityl chlorides, Microwave irradiation, Nucleosides, Selectivity

 

 

Bull. Chem. Soc. Ethiop. 2010, 24(2), 299-304.
Published
2010-05-26
Issue
Vol. 24 No. 2 (2010)
Section
Articles

Journal Identifiers


eISSN: 1726-801X
print ISSN: 1011-3924