PROMOTING ACCESS TO AFRICAN RESEARCH

Bulletin of the Chemical Society of Ethiopia

Log in or Register to get access to full text downloads.

Remember me or Register



A catalytic method for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres as nonsteroidal cardiotonic agents

Yahia Sh. Beheshtia, Maliheh Khorshidi, Majid M. Heravi, Bita Baghernejad

Abstract


A highly efficient procedure for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres via a one-pot multicomponent reaction of 3,4-dimethoxyacetophenone, malonitrile or ethyl cyanoacetate, an aldehyde and ammonium acetate in the presence of K2CO3 is achieved in good yields.

 

KEY WORDS: 3-Cyano-2(1H)-pyridinones, 2-Imino, Cardiotonic, Dimethoxyacetophenone

 

 

Bull. Chem. Soc. Ethiop. 2010, 24(3), 433-438.




http://dx.doi.org/10.4314/bcse.v24i3.60691
AJOL African Journals Online