A catalytic method for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres as nonsteroidal cardiotonic agents

  • Yahia Sh. Beheshtia Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran
  • Maliheh Khorshidi Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran
  • Majid M. Heravi Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran
  • Bita Baghernejad Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran
Keywords: 3-Cyano-2(1H)-pyridinones, 2-Imino, Cardiotonic, Dimethoxyacetophenone

Abstract

A highly efficient procedure for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres via a one-pot multicomponent reaction of 3,4-dimethoxyacetophenone, malonitrile or ethyl cyanoacetate, an aldehyde and ammonium acetate in the presence of K2CO3 is achieved in good yields.

 

KEY WORDS: 3-Cyano-2(1H)-pyridinones, 2-Imino, Cardiotonic, Dimethoxyacetophenone

 

 

Bull. Chem. Soc. Ethiop. 2010, 24(3), 433-438.

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eISSN: 1726-801X
print ISSN: 1011-3924