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<b>N-6 substituted deoxygenated derivatives of L-like 5'-noraristeromycin</b>

Henry Yu
Tesfaye Serbessa


Several N-6 substituted derivatives (4-11) of (+)-4'-deoxy-5'-noraristeromycin (2) and its unsaturated counterpart (3) have been prepared. The derivatives are designed to systematically vary the hydrophobic/hydrophilic balance of the lead compounds. These compounds were evaluated against a large number of viruses but no significant antiviral activity was observed. Also, no cytotoxicity to host cells was found.


KEY WORDS: L-like, Carbocyclic nucleosides, HBV



Bull. Chem. Soc. Ethiop. 2010, 24(3), 439-446.

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eISSN: 1726-801X
print ISSN: 1011-3924