Symphonin: A new prenylated pyranoxanthone With antimicrobial activity from the seeds of Symphonia globulifera (guttiferae)

  • Bruno N. Lenta Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
  • Silvere Ngouela Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
  • Diderot T. Noungoue Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
  • Etienne Tsamo Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
  • Joseph D. Connolly Department of Chemistry, The University, Glasgow G 12 8QQ, U.K.
Keywords: Symphonia globulifera, Seeds, Xanthone, Antimicrobial activity

Abstract

A new prenylated pyranoxanthone, symphonin (1), 2-(3,3-dimethylallyl)-1,5- dihydroxy-6,7-dimethoxy-2”,2”-dimethylpyrano (5”,6”:3,4) xanthone, the known compounds guttiferone A, oleanolic acid and  sitosterol  were isolated from the methanol extract of the seeds of Symphonia globulifera (Guttiferae). The structural elucidation of the new compound was based mainly on spectroscopic analyses. The new xanthone showed antimicrobial activity against Staphylococcus aureus, Streptococcus feacalis, Klebsiella pneumonia and Escherichia coli.

 

KEY WORDS: Symphonia globulifera, Seeds, Xanthone, Antimicrobial activity

 

 

Bull. Chem. Soc. Ethiop. 2004, 18(2), 175-180.

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Articles

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eISSN: 1726-801X
print ISSN: 1011-3924