A splendid method for synthesis of 2-(benzothiazole)-3-phenyl acrylonitrile derivatives catalysed by piperdine
A simple and efficient method is developed for the synthesis of 2-(benzothiazol-2-yl)-3-(substituted phenyl)acrylonitrile from 2-(benzothiazole-2-yl)-3-oxopentanedinitrile and aromatic aldehydes in the presence of a catalytic amount of piperdine into ethanol at reflux. Advantage of this procedure is relatively good yields (81-86%) with short reaction times (1.5-3 h), under moderate reaction conditions and simple workup procedure, plus easy preparation and handling of the catalyst.
KEYWORDS: 2-(Benzothiazole)-3-phenylacrylonitrile, One-pot synthesis, 2-(Benzo-thiazole-2-yl)-3-oxopentanedinitrile, Aromatic aldehydes, Piperdine
Bull. Chem. Soc. Ethiop. 2012, 26(3), 467-471.