Histomorphological analysis of <i>Carica papaya</i> and <i>Phyllanthus niruri</i> treatment potentials on testicular tissue of albino rats pre-treated with nitrofuratoin

Abstract

Background: Herbal medicine is a natural product from plants and has proven overtime to be useful in so many areas since the days of old and still in  use today.

Aim: The research item is aimed at evaluating the remedial changes associated with Carica papaya and Phyllanthus niruri treatment on testicular tissue  of rats pre-treated with Nitrofuratoin.

Materials and Methods: The research was divided into two stages, in the first stage, group 1, received water and pelleted rat feed, group 2-5 received,  100 mg/kg body weight of nitofuratoin and served as control and test respectively. In the phase 2, group 1, received rat pellet and water ad lithium,  group 1-2, received rat pellet and water, group 3- 5 received 100 mg/kg body weight of P. niruri, C. papaya, equal of P. nuriri and Carica papaya  respectively. After two weeks of administration, In stage 1, four animals in control and 4 in test. In the stage 2, all animals were weighed, euthanized and  sacrificed and the vas deferens, and other part of the testicular tissues were harvested, analyzed, processed, stained and examine.

Results: The result  shows that nitrofurantoin caused distortion in the seminiferous tubule, affected the sperm cell morphology which was in turn remedied by C. papaya, P.  niruri and combined.

Conclusion: The herbal medicines have remedial potentials on damage tissue.