Adenosine and its Related Nucleotides may Modulate Gastric Acid Secretion by Inhibiting Calcium Permeability
Studies on lumen-perfused rat isolated stomachs showed that adenosine, adenosine monophosphate (AMP) and reduced nicotinamide adenine dinucleotide (NADH) inhibited histamine-induced gastric acid secretion. The inhibitions and the calcium levels of the serosal solution exhibited inverse relationship. Adenosine and AMP were shown to antagonise calcium-induced swelling of mitochondria. It was thus thought, by extension, that inhibition of calcium entry might be one of the mechanisms by which the purines regulate gastric functi
Keywords:Purines: Gastric hypoacidity; anti-mitochondrial swelling
Bio-Research Vol. 6 (1) 2008: pp. 348-350
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