Adenosine and its Related Nucleotides may Modulate Gastric Acid Secretion by Inhibiting Calcium Permeability

  • OFC Nwodo
  • CI Ezekwe
  • AV Iwueke
  • UO Njoku
Keywords: Purines, Gastric hypoacidity, anti-mitochondrial swelling

Abstract



Studies on lumen-perfused rat isolated stomachs showed that adenosine, adenosine monophosphate (AMP) and reduced nicotinamide adenine dinucleotide (NADH) inhibited histamine-induced gastric acid secretion. The inhibitions and the calcium levels of the serosal solution exhibited inverse relationship. Adenosine and AMP were shown to antagonise calcium-induced swelling of mitochondria. It was thus thought, by extension, that inhibition of calcium entry might be one of the mechanisms by which the purines regulate gastric functi

Keywords:Purines: Gastric hypoacidity; anti-mitochondrial swelling

Bio-Research Vol. 6 (1) 2008: pp. 348-350
Published
2009-01-06
Section
Articles

Journal Identifiers


eISSN: 2705-3822
print ISSN: 1596-7409