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Dose and duration dependent of aluminium in the serum liver and the brain of male Wistar albino rat

PN Ogueche, UE Nwachi, O Obidoa

Abstract


An atomic absorption spectrophotometric analysis on dose and duration dependent aluminum concentration in serum, liver and brain digests of three groups of male Wistar albino rats were investigated after seven and fourteen days of daily 0.38mg/kg, 3.8mg/kg and 38mg/kg aluminum administration respectively. The results showed that the test animals given the highest dose of (3.8mg/kg bw) of toxicant increase significantly (p<0.05) in aluminum concentration in serum, liver and brain digest after seven days when compared to the control animals. However, the mid and highest dose (38 and 38mg/kg bw) of toxicant significantly increased (p<0.05) in aluminum concentration in all the digest after fourteen days of exposure to aluminium. It is therefore concluded that increase in aluminum administration in male Wistar albino rats may predispose the animals to increase in aluminium concentration in the serum, liver and brain which is dose and duration dependent.



http://dx.doi.org/10.4314/br.v7i1.45460
AJOL African Journals Online