Preformulation compatibility screening of dika fat-drug mixtures using differential scanning calorimetry

Abstract

Differential scanning calorimetry (DSC) was used as screening technique for assessing compatibility between dika fat and drug substances. Dika fat was found to be compatible with aspirin, ascorbic acid, paracetamol, sulphanilamide, phenylpropanolamine hydrochloride, bromopheniramine maleate, chlorpheniramire maleate, diazepam, phenobarbital, phenobarbital sodium, phenylpropanolamine hydrochloride and propranolol hydrochloride. It appears that dika fat can be used as a formulation aid in medicinal or veterinary products containing any of these substances. It was found that dika fat may interact with ephedrine hydrochloride, norgestrel and atropine sulphate.