Preformulation compatibility screening of dika fat-drug mixtures using differential scanning calorimetry
Abstract
Differential scanning calorimetry (DSC) was used as screening technique for assessing compatibility between dika fat and drug substances. Dika fat was found to be compatible with aspirin, ascorbic acid, paracetamol, sulphanilamide, phenylpropanolamine hydrochloride, bromopheniramine maleate, chlorpheniramire maleate, diazepam, phenobarbital, phenobarbital sodium, phenylpropanolamine hydrochloride and propranolol hydrochloride. It appears that dika fat can be used as a formulation aid in medicinal or veterinary products containing any of these substances. It was found that dika fat may interact with ephedrine hydrochloride, norgestrel and atropine sulphate.Bio-Research journal is an open access journal, which means all its content is freely available without charge to the user or his/her institution.
You are free to share (that is, copy and redistribute the material in any medium or format) as long as you follow these licence terms:
Attribution (by)
You must give appropriate credit, provide a link to the license.
Non Commercial (nc)
You can copy, distribute, display, perform, and use this material for any purpose other than commercially (unless you get permission first). Non Commercial means not primarily intended for or directed towards commercial advantage or monetary compensation.
No Derivatives (nd)
If you remix, transform, or build upon the material, you may not distribute the modified material. But note that simply changing the format does not create a derivative.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the licence permits.
Notices
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
