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Anti-craving Property of Chlorpromazine in Pentazocine addiction among sickle cell disease patients: A Case Series


Background: Opioids are useful in the management of vaso-occlusive crisis among Sickle Cell Disease patients; however, there is a need to search for drugs that can ameliorate the withdrawal symptoms without causing further dependence.

Case presentations: Three patients living with Sickle cell disease abusing Pentazocine were managed with Tab Chlorpromazine 100mg twice daily for three weeks and had a significant reduction in the level of craving and also experienced improved sleep. Chlorpromazine demonstrates a high affinity for dopamine (DA) receptors and acts as a receptor antagonist by inhibiting adenylate cyclase activity. 

Conclusion: Chlorpromazine was found to be useful in the management of cravings associated with Pentazocine addiction.

Journal Identifiers

eISSN: 2756-4657
print ISSN: 2465-6666