Quantitative Phytochemical and LCMS/MS Analysis of Guiera senegalensis Aqueous and Methanol Leaf Extracts

Abstract

Guiera senegalensis is a vital medicinal plant in African traditional medicine which has been acknowledged for its therapeutic efficacy. It  is conventionally linked to numerous pharmacological actions, including anti-inflammatory, antibacterial, anticancer, cardioprotective,  neuroprotective, and antiallergic characteristics. Nonetheless, a comprehensive understanding of its phytochemical makeup and  bioactive components is still constrained. This work sought to examine the quantitative phytochemical composition of Guiera  senegalensis leaf and also to conduct a comprehensive analysis of its bioactive components using LC-MS/MS. Aqueous and methanol leaf  extracts of Guiera senegalensis were subjected to LC-MS/MS analysis to identify distinctive bioactive components. The study  identified 46 phytoconstituents, comprising galloylquinic acid derivatives, phenolic acids, flavonoids, tannins, beta-carboline alkaloids,  naphthopyrans, and alkaloids. The study emphasizes the health benefits of this plant and its significance as a vital resource in African  traditional medicine, facilitating further research and development. Studies are currently on-going to isolate the compounds in their pure  forms in order to elucidate and characterize their structures using different spectroscopic techniques.