Soaps and Germicides as Adjunct Topical Antimycotic Agents on Candida species Implicated in Vulvovaginal Candidasis

Abstract

Objective: The study aims at evaluating the potentials of soaps and  germicides / disinfectants as adjunct topical anti-vulvovaginal candidasis agents.
Methods: In vitro inhibitory activities of the test agents, prepared according to the manufacturer’s specification for toilet and midwifery purposes were determined using modified agar well-diffusion method.
Results: Varied susceptibility patterns were exhibited by Candida albicans (26.5%), C. glabrata (18.4%), C. pseudotropicalis (14.3%) and C.  tropicalis (40.8%) implicated in vulvovaginal candidasis, indicating  Crusader oil (100%), Meriko (95%), Tetmosol (84.7%) and Aloe (68.4%) as the most inhibitory soaps against the Candida strains. The in vitro inhibitory activities of the germicides and disinfectants ranged between (Dettol; 34.6% and Purit; 84.6%) for C. albicans; (Roberts; 33.3% and Purit; 83.3%) for C. glabrata; (Roberts; 21.4% and Purit; 92.9%) for C. pseudotropicalis; (Dettol; 35.0% and Purit; 87.5%) for C. tropicalis respectively. All the Candida strains were totally inhibited by the germicides and disinfectants at the second lower dilutions, except in Morigad towards C. albicans (69.2%]) C. glabrata (72.2%), C. pseudotropicalis (92.9%) and C. tropicalis (82.5%) but none of the vaginal Lactobacillus strains was inhibited by the soaps, germicides or disinfectant. About 90% of a control group indicated relief after pubic cleansing with soaps, germicides and disinfectants.
Conclusion: Results indicatied the safety of soaps, germicides and  disinfectants as potential adjunct topical cleansing-agents in cases of vaginal itching and candidasis, a common mucosal infection caused by
opportunistic yeasts of the Candida genus.

Keywords: Candida, candidasis, disinfectants/germicides, soaps, women’s health, vaginal itching