Population Prevalence of First and Second-Degree Family History of Breast and Ovarian Cancer

Abstract

Background: Family cancer history is an important risk factor for common cancers, thus, recognizing pattern of familial cancer can help us to identify individuals who may have higher chance to develop specified cancers.
Methods: This cross-sectional survey assessed family history of cancer in first- and second degree relatives. Totally, 7,300 persons aged 20 years selected by random sampling from Tehran general population. Age- and sex-specified prevalence of breast and ovarian cancer in respondent's family was calculated.
Results: Of all, 279(4.3%) individuals reported a history of breast or ovarian cancer in their relatives. The prevalence of breast cancer family history was 1.8% among first-degree relatives and 2.5% among second- degree relatives. For ovarian cancer, first- and seconddegree prevalence ranged from 0.05 to 0.12%. Those with family history of cancer were more often young and female.
Conclusions: Overall, the estimates of prevalence presented here are likely to be conservative compared with actual current prevalence because of some limitations. While family history is an important risk factor for common cancers such as breast cancer, recognizing pattern of familial cancer that signify increased risk can help us to identify individuals who may have higher chance to develop specified cancers.

Keywords: Family history, Breast cancer, Ovarian cancer, Prevalence, Cross-sectional, Self-report.