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Male factor is one of the most frequent cause of infertility and presents a variety of endocrine, genetic and immunological etiologies, as well as sexual malfunction, varicocele and genital infections. A case of a couple with primary infertilityfor two years is presented. Both partners were evaluated thoroughly, with a finding of male infertility. The man was found to be azoospermic after two semenalysis were performed. The Follicle Stimulating hormone (FSH) was raised with low testosterone levels indicating testicular failure. The recommended treatment was testicular biopsy with cryopreservation of the sperm and subsequent Intra cytoplasmic Sperm Injection (ICSI). This treatment option was undertaken with successful implantation and live baby delivery. The case study presents the diagnostic modalities and management of male infertility with azoospermia.