Case control study to investigate correlation between vitamin D deficiency and pre-diabetes in Arar, Saudi Arabia
Introduction: Pre-diabetes is associated with abdominal obesity, insulin resistance, non-alcoholic fatty liver disease and metabolic syndrome, and such individuals are at an increased risk for developing type-2 diabetes mellitus.
Methods: A total of 60 research subjects, all of them at least thirty years or older, were divided into two groups of 30 pre-diabetics and 30 normoglycemics. The subjects exhibiting diabetes, kidney, liver and heart diseases and pregnancy were excluded from the study. The fasting plasma glucose level and vitamin D level were measured.
Result: Pre-diabetic subjects were found to have significantly lower levels of vitamin D than compared to normoglycemic subjects with median levels of 17.68 and 31.72 mmol/l respectively (P=0.000).
Conclusion: It was found that vitamin D deficiency plays a significant role in the development of pathogenicity of type 2 diabetes mellitus.