Renal ultrasonographic findings relative to CD4+ cell count in HIV positive adults in South Nigeria
Objectives: This study evaluated the renal sonographic changes in HIV positive patients in Port-Harcourt, south south Nigeria; to determine the relationship, if any, to CD4+ cell count in the study population.
Design: A prospective descriptive study.
Setting: University of Port Harcourt Teaching Hospital (UPTH), Port Harcourt, Nigeria.
Results: There were 260 patients (80 males and 180 females), aged 22 to 75 years with a mean age of 36.0 ± 8.7years. Females had significantly higher CD4+ cell count than males (427±304 cells/mm3 vs. 344.7±266.8 cells/mm3 , p=0.036). Renal sonographic abnormalities were commoner in patients with very low CD4+ cell counts (<200 cells/mm3 ). Loss of corticomedullary echo differentiation was commoner with reducing CD4+ cell count.
Conclusion: Renal sonographic features in HIV patients in the study area are characterized by increased renal parenchymal echogenicity, loss of corticomedullary differentiation and increased right renal cortical thickness with decreasing CD4+ cell count. Thus, the use of renal ultrasound in
evaluation of HIV positive patients is advocated as early detection and management of renal abnormalities will reduce renal morbidity associated