Effects of hypokinesia on cyclic nucleotides and hormonal regulation of calcium metabolism in rats

  • J. B.L. Chek
  • A. I. Laniko


Objective: To study the dynamic of changes in the level of parathyroid hormone (PTH), calcitonin (CT), cyclic nucleotides (cAMP, cGMP) and calcium in the blood of rats, while in urine - phosphate, calcium and cyclic nucleotides.

Design: Laboratory based experiment.
Setting: Laboratory in the Department of Biochemistry, Faculty of Medicine, University of Nairobi, Nairobi, Kenya and in the Department of Biochemistry, Kharkov State University, Ukrain Republic.
Results: Correlation between the changes in the parameters of study was shown. This supports the theory about the relationship between branches of hormonal systems (cyclic nucleotides - calcium), which perform the central role in the regulation of homeostasis. The results show that daily excretion of calcium and phosphate is age dependent in rats during the pathogenesis of hypokinesia: the values are higher in control groups. Changes in calcium in the blood and phosphaturia in the experimental animals of all ages were attributed to changes in the intensive re-absorption process within the bones during the readaptation period of hypokinesia.
Conclusion: Old rats have a higher ability to adaptation than younger experimental counterparts during hypokinesia.

(East African Medical Journal: 2002 79(4): 210-213)

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