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Objectives: To determine the glomerular filtration rate profiles of paediatric oncology patients and to assess changes that had occured over a period of at least six months of continuing cancer chemotherapy.
Design: Cross-sectional hospital based survey.
Setting: General Paediatric wards, including Paediatric Oncology and Paediatric Ophthalmology ward. Kenyatta National Hospital, Nairobi, Kenya.
Subjects: Paediatric patients who had an established diagnosis of cancer and had been on chemotherapy for at least six months.
Results: Out of the 115 children enrolled in the study 43 had abnormal kidney function. This gave a prevalence of 37% (95%CI 28-46).The other 72 children had normal kidney function. Patients aged less than five years and those with solid tumors had a higher likelihood of having an abnormal GFR compared to their older counterparts and those with lymphomas and leukemias.
Conclusions: Monitoring of GFR should be done regularly as decline occurs as one continues on chemotherapy especially for the ones below five years and those with solid malignancies.