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Principles and practice of gamma knife radiosurgery: a review


V Rahimi-Movaghar
JC Flickinger

Abstract

Objectives: To determine the physics, biology, outcomes and risks of gamma knife radiosurgery (GKRS) in treating brain tumours, arteriovenous malformations (AVMs), pain and movement disorders.

Data sources: A retrospective MEDLINE search was used to find all gamma knife radiosurgery studies published from 1967 to 12th March 2005 and strict inclusion criteria were applied.

Study selection: Limited to the review articles in the human study with the key word of gamma knife radiosurgery.

Data extraction: In each subject, both authors reviewed related articles separately.

Data synthesis: Adding up data and compare the results.

Conclusions: The GKRS represents one of the most advanced means available to treat brain tumours, arteriovenous malformations (AVMs), pain and movement disorders safely and effectively. At present, the long-term results after GKRS procedures remain to be documented. The physics, biology, current indications and expected outcomes after GKRS are discussed.

East African Medical Journal Vol. 83(7) 2006: 393-400

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eISSN: 0012-835X