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Ong’ang’o, H., & Jones, R. (2012). Pathological Fracture due to pemphigus vulgaris: A case report. East African Orthopaedic Journal, 6(2), 84–86. https://doi.org/10.4314/eaoj.v6i2.
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Pathological Fracture due to pemphigus vulgaris: A case report
Abstract
Pemphigus vulgaris is a rare but serious autoimmune mucocutaneous bullous disease.The two cardinal pathological processes at work are a split within the epidermis and loss of adhesion of epidermal cells (Acantholysis). It is due to deposition of pathogenic IgG on the Keratinocyte cell surface. The mainstay of treatment is systemic corticosteroids and bone complications have been noted to arise from this treatment. Pathological fracture due to pemphigus vulgaris before commencement of corticosteroid treatment has not been reported before in the world literature.
