Brine Shrimp Lethality of Alkaloids from Croton sylvaticus Hoechst

  • MC Kapingu
  • ZH Mbwambo
  • MJ Moshi
  • JJ Magadula

Abstract

Three compounds were isolated from the leaves of Croton sylvaticus (Euphorbiaceae) and evaluated for their brine shrimp lethality. Julocrotine, a glutarimide alkaloid, was very toxic in vitro with a LC50 (95% confidence interval) value of 0.074 (0.052-0.105) μg/ml. Lupeol and penduliflaworosin were not toxic. The structures of the isolated compounds were determined by spectroscopic methods.

Keywords: Croton sylvaticus, Euphorbiaceae, julocrotine, lupeol, penduliflaworosin, brine shrimp lethality

East and Central African Journal of Pharmaceutical SciencesVol. 15 (2012) 35-37

Author Biographies

MC Kapingu
Muhimbili University College of Health Sciences, Institute of Traditional Medicine, P.O. Box 65476, Dar es Salaam, Tanzania
ZH Mbwambo
Muhimbili University College of Health Sciences, Institute of Traditional Medicine, P.O. Box 65476, Dar es Salaam, Tanzania
MJ Moshi
Muhimbili University College of Health Sciences, Institute of Traditional Medicine, P.O. Box 65476, Dar es Salaam, Tanzania
JJ Magadula
Muhimbili University College of Health Sciences, Institute of Traditional Medicine, P.O. Box 65476, Dar es Salaam, Tanzania
Published
2014-09-10
Section
Articles

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eISSN: 1026-552X