Phytochemical and anthelmintic study of the root bark of <i>Teclea trichocarpa</i>, Engl. (Rutaceae)

Abstract

The root bark of Teclea trichocarpa exhibited anthelmintic activity against egg hatching and larval development of sheep nematodes (Strongyloides). Three compounds, namely lupeol, melicopicine and 6-methoxytecleanthine were isolated from the dichloromethane-methanol (50:50) extract of the plant. Melicopicine and 6-methoxytecleanthine exhibited mild anthelmintic activity. The present study lends scientific credence to the traditional use of Teclea trichocarpa in the treatment of human helminth infections.

Keywords:  Teclea trichocarpa, phytochemical, anthelmintic