Quality of Antiretroviral Drugs Analyzed in the Drug Analysis and Research Unit During 2000-2003

  • KO Abuga Drug Analysis and Research Unit, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya
  • PM Mwagiru Drug Analysis and Research Unit, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya
  • GN Thoithi Drug Analysis and Research Unit, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya
  • JM Nguyo Drug Analysis and Research Unit, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya
  • JK Ngugi Drug Analysis and Research Unit, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya
  • OK King'ondu Drug Analysis and Research Unit, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya
  • HN Mugo Drug Analysis and Research Unit, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya
  • IO Kibwage Drug Analysis and Research Unit, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya
Keywords: Antiretroviral, assay, dissolution, nucleoside reverse-transcriptase inhibitor

Abstract

During the period 2000-2003 the Drug Analysis and Research Unit received and analyzed 33 samples of antiretroviral drugs. Locally manufactured products accounted for 57.6 % of the samples, while the imported drugs constituted 42.4 %. The drugs consisted of single, double and triple component preparations. They were subjected to the identity, assay and dissolution tests. 30 samples (90.9 %) complied with compedial specifications for these tests, while 3 failed. The results obtained show that manufacture of quality generic antiretroviral drugs is achievable.
Key Words: Antiretroviral, assay, dissolution, nucleoside reverse-transcriptase inhibitor
East & Central African Journal of Pharmaceutical Sciences Vol.6(1) 2003: 20-23
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eISSN: 1026-552X