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Egyptian Journal of Biochemistry and Molecular Biology

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Evaluation Of Oxidative Stress And Apoptosis In Breast Cancer

RM Farag, MB Ahmed, MA El-Ghendy, IS Mohamed

Abstract


Reactive oxygen species are important in the pathogenesis of many
diseases, including breast cancer. In this study, we aimed to evaluate
oxidative stress in patients with breast cancer and to investigate its
relationship with apoptosis. Our results showed that, the median levels
and positivity rates of Malondialdehyde (MDA), Nitric Oxide (NO),
Total Antioxidant (TAO), caspase-3, %DNA fragmentation and
MDA/TAO ratio measured in breast cancer tissues by colorimetric
methods were higher in the malignant group as compared to benign
control group. Moreover, MDA, NO and %DNA fragmentations were
over produced in advanced grade and stage P‹ 0.05. Furthermore, a
significant positive correlation was found between MDA/TAO ratio
and positive lymph node metastasis. Also, there were significant
positive correlations of caspase-3 and %DNA fragmentation with
positive estrogen receptor and NO. Moreover, the total antioxidants
were positively correlated with positive progesterone receptor. In
Conclusion; oxidative stress, NO and apoptosis are highly detected in
breast cancer tissues especially with advanced grade and stage.
Key words: Breast cancer, Reactive Oxygen Species (ROS),
malondialdehyde (MDA), Nitric Oxide (NO), Total Antioxidants
(TAO), Caspase-3 and DNA fragmentation.

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http://dx.doi.org/10.4314/ejbmb.v27i2.49254
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