The impact of <i>Morus alba</i> leaves extract on neurotransmitters & apoptosis experimental diabetic rats

Abstract

Diabetes mellitus is one of the most common endocrine diseases. Researchers all over the world are exploring herbal supplements to control diabetes and its complications. This study evaluated the antidiabetic action of Morus alba leaves extract through its effect on hyperglycaemia, DNA damage and apoptosis of brain cells due to oxidative stress in diabetes. Moreover, evaluate the effect of diabetes on neurotransmitters levels of streptozotocin-induced diabetic rats. Application of crude water extract of Morus alba resulted in amelioration of the alterations of serum glucose as well as neurotransmitters including acetylcholine, nor-adrenaline, serotonin, histamine, dopamine, and gamma amino butyric acid). Furthermore, Morus alba leaves leaf extract display hypoglycemic effect, diminish DNA damage and apoptosis of brain cells of diabetic rats. In conclusion ,our results suggest that The protective effect of Morus alba leaves extract could be attributed to the  hypoglycaemic, and antioxidative potential of flavonoids, the major components of the plant extract.

Keywords: Morus alba,ACE,NAD,DA,GABA