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Egyptian Journal of Medical Human Genetics

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Association of P2X7 gene common polymorphisms with pulmonary tuberculosis in Lur population of Iran

Ali Amiri, Toomaj Sabooteh, Seyyed Amir Yasin Ahmadi, Alireza Azargoon, Farhad Shahsavar

Abstract


Background: Different genetic and environmental factors are associated with susceptibility to pulmonary tuberculosis (TB) in different individuals of different populations. Based on previous studies role of P2X7 gene common polymorphisms in susceptibility to pulmonary TB was associated with ethnicities.

Aim: We intend to perform this study on genetic reservoir (gene pool) of Lur population of western Iran.


Methods: For the present case-control study, 100 unrelated pulmonary TB patients and 100 unrelated controls were enrolled through convenient  sampling. TB confirmation was through smear and culture of sputum.  Polymerase chain reaction with restriction fragment length polymorphism (PCR-RFLP) was used for molecular assay. This study has been approved in the ethic committee of Lorestan University of Medical Sciences with registration number LUMS.REC.1396.253.


Results: Among the genotypes of polymorphism 1513A/C, AA genotype was associated with susceptibility to pulmonary TB (P = .0001; OR = 4.750) whereas AC genotype was a protecting factor (P = .0001; OR = 0.192). Higher genetic reservoir of A allele was associated with more susceptibility to pulmonary TB (P = .0001; OR = 2.879) whereas C allele was a protecting factor (P = .0001; OR = 0.347). No significant result was found for 762T/C polymorphism.


Conclusion: In Lur population of Iran, 1513A/C polymorphism of P2X7 is associated with susceptibility to pulmonary TB. It is suggested that bio-information banks should be established and developed in countries.




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