Egyptian Journal of Medical Human Genetics

Log in or Register to get access to full text downloads.

Remember me or Register

Craniofacial proportions and anthropometric measurements among growth hormone deficient Egyptian children

M Rashad, N Amr, ME Badwy, H Elsedfy


Introduction: Untreated children with growth hormone deficiency (GHD) have typical somatic features, including short stature, acromicria and distinctive craniofacial features including small head circumference. Patients and Methods: By using a cross sectional study design, we investigated the effect of GHD on craniofacial growth with photographic facial morphometrics & various anthropometric measurements, in 20 children with GHD compared with 20 healthy children and normal first degree relatives of
the same age and sex group. Results: Untreated children with GHD had retarded facial height & width (p<0.01) compared with the control group. Moreover all anthropometric
measurements (weight, height, head circumference, sitting height, arm span and sub-ischial leg length) were reduced in GHD children in comparison to controls (p<0.01) except ear length which was above 3rd percentile. Also small head circumference for chronologic age and for height age was observed in GHD children (p<0.01). In addition small hands and feet for age (below 3rd percentile) were found in untreated GHD children when compared with
normal controls. This report validates & quantifies the clinical impression of foreshortened facies in GHD children.

Keywords: Growth hormone deficieny, anthropometric measurements, craniofacial proportion.

Egyptian Journal of Medical Human Genetics Vol. 9 (2) 2008: pp. 161-170

AJOL African Journals Online