Relationship between Thyroid Functions and Estimated Glomerular Filtration Rate in Patients with Chronic Kidney Disease

Abstract

Background: Chronic kidney disease (CKD) stands for a gradual decline in renal function occurring over months or years. Thyroid  hormones exert specific influences on cellular differentiation as well as growth. The interaction between the thyroid and kidney in their  respective functions has been recognized for several years. Thyroid dysfunction influences renal development as well as physiology, while  kidney diseases may lead to thyroid dysfunction.

Objective: Our research was carried out to assess the correlation between  thyroid function and estimated GFR among CKD cases. 

Patients and methods: Our team designed a cross-sectional study including 117  cases developing CKD of varying etiology but not undergoing hemodialysis. Participants underwent a categorization based on GFR,  measured by the " CKD Epi Formula" that fell between 15.1 and 58.2 ml/min/1.73 m² into, group 1 involved cases developing CKD stage 3a, GFR (45-59), group 2 involved cases developing CKD stage 3b, GFR (30-44) and group 3 involved cases developing CKD stage 4, GFR  (15-29). 

Results: TSH exhibited a significant increase within group 3 as opposed to (group 1 and group 2). Anti TPO and antithyroglobulin  showed an insignificant variation among the three stages of GFR classification and no significant association was seen between GFR and  (anti TPO and anti-thyroglobulin). A significant positive association was observed between TSH and (ACR and GFR). Free T3 and free T4  showed an insignificant variation among the three levels of ACR. Asignificant positive association was also documented between (anti  TPO, anti-thyroglobulin) and ACR. No association was observed between GFR and (FT3, FT4, anti TBO, anti-thyroglobulin).

Conclusion: In  CKD cases of varying etiology but not undergoing hemodialysis, a significant positive association was reported between TSH and (serum  urea, creatinine, ACR) and between ACR and (anti TPO and anti-thyroglobulin). A significant negative association was documented  between TSH and GFR.