Studies On The Effects Of An Alcohol Extract Of The Leaves Of Telfairia occidentialis On Alloxan Induced Diabetic Rats

  • A Olorunfemi Eseyin Department of Pharmaceutical and Medicinal Chemistry, University Of Uyo
  • C Arnold Igboasoiyi Department of Pharmaceutical and Medicinal Chemistry, University Of Uyo
  • Herbert Mbagwu Dept. of Pharmacology and Toxicology, Faculty Of Pharmacy, University Of Uyo
  • Ekaete Umoh Department of Pharmaceutical and Medicinal Chemistry, University Of Uyo
  • FJ Ekpe Department of Pharmaceutical and Medicinal Chemistry, University Of Uyo
Keywords: Telfairia occidentalis, diabetes, biochemical parameters

Abstract

The effect of 96% ethanol extract of the leaf of Telfaria ocidentalis on alloxan induced diabetic rats were investigated. A dose of 500mg/kg of the extract was orally administered daily to the test animals for 9 days while the control animals received saline. The following biochemical parameters were evaluated: haemoglobin, glucose, cholesterol, total protein, proteins fractions, Alanine Amino transferase (ALAT) and Aspartate Transaminase (ASAT) levels. The weight of animal were also monitored. Glucose concentration and ASAT/ALAT quotient increased while ALAT activity decreased significally in the test animal compared with control (p<0.05). The extract also enhanced the growth of the diabetic animals. The extract did not show hypoglycemic effect.
KEY WORDS: Telfairia occidentalis, diabetes, biochemical parameters.
Global Journal of Pure and Applied Sciences Vol.11(1) 2005: 77-79
Published
2005-02-18
Section
Articles

Journal Identifiers


eISSN: 1118-0579