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Topographic Anterograde and Retrograde Memory for Spatial Behaviour Effects of Haloperidol Treatments in Long Evan Rats

V Ucheagwu, O Jesse


The present study was on the effects of haloperidol injection on anterograde and retrograde topographic memories for spatial behaviours in Long Evan rats. Twelve Long Evan albino rats weighing 0.5 – 0.8 kg (6 males, 6 females) were used for the study. Complex Maze Box of 14 unit T Alley from the Royal Institute of Psychologists, Nigeria were used for spatial learning trials while Haloperidol injection treatment from AGILA SPECLTS Company was used. The subjects were divided into 2 groups: retrograde and anterograde groups. The Mann Whitney U test and Wilcoxon Rank sum statistics were used for data analysis. The findings showed significant differences between retrograde group: before injection and after injection on time spent to run the maze. Similarly significant difference was seen between the retrograde group (before injection) and anterograde group at P<0.03. In addition, significant difference was also found between the retrograde group (after injection) and anterograde group. Overall, the findings showed that retrograde memory is more affected by haloperidol injection followed by anterograde memory when compared to rats that received no injection. The findings thus implicated haloperidol injection drug in retrograde and anterograde spatial memories in the subjects.

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