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Isolation and antibacterial activity of triterpenes from <i>Euphorbia kamerunica</i> Pax
Abstract
Two known compounds, friedelin and epifriedelinol were isolated from Euphorbia kamerunica Pax. The compound’s structures were established on the basis of spectral analysis. The antibacterial activities of these compounds and the ethyl acetate extract were established on Pseudomonas aeruginosa, Salmonella typhii and Staphylococcus aureus. The extract displayed higher inhibition activities on the bacteria than the isolated compounds. The zones of inhibition of the extracts were between 9.0 and 30.5 mm, with the highest extract activity on Staphylococcus aureus. The minimum inhibition concentration (MIC) values of the isolated triterpenes were between 7.5 - 10 μg/ml.
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Keywords: Euphorbia kamerunica, friedelin, epifriedelinol, antibacterial activity, MIC.
