Article Sidebar
Article Details
Submission of a paper for publication implies the transfer of the copyright from the author(s) to the publisher upon acceptance. International Formulae Group is therefore the copyright holder after publication of an article in International Journal of Biological and Chemical Sciences, and published articles should not be used for commercial purpose without the written consent of the Editor-in-Chief. They are licensed under a Creative Commons Attribution-Non Commercial-Share Alike 4.0 International License.
Main Article Content
Comparative anticancer activity of dolaborane diterpenes from the roots of <em>Ceriops tagal</em> (Rhizophoraceae)
Abstract
This study aimed at investigating the anticancer activity of tagalsins A, B, C, D, E, F and G isolated from the roots of Ceriops tagal. Their structures were established based on the IR, MS and NMR spectral data. Anticancer activity was evaluated using caspase-3 colourimetric assays and the minimum activation concentrations were established. The study revealed that tagalsin A, B, C, D, E, F and G induces apoptosis through the activation of caspase-3 enzyme. Tagalsin A was the most active (MAC value of 0.12 μg/mL) followed by tagalsin B (MAC of 0.15 μg/mL) and and tagalsin E was the least active (MAC value of 1.16 μg/mL). Structure activity relationship revealed that epoxide rings and oxygenation enhanced the activity of tagalsins in inducing caspase-3 activation of apoptotic pathway, thus, providing an avenue for the development of anticancer agents with novel mechanism of actions.
Keywords: Ceriops tagal, dolaboranes, tagalsins, caspase-3
