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Some physiochemical changes associated with type 2 diabetes mellitus in Benin City, Nigeria


FA Ehiaghe

Abstract

The present study was designed to determine the level of malondialdehyde (MDA) concentration, serum c reactive protein (CRP) and CD4+ T cells in type 2 diabetes mellitus in a view to assessing the complications associated with the non specific activation of CD4+ T cells. A total of 80 subjects aged between 18 and 50 years gave their consent to participate in the study. They consist of 40 known type 2 diabetes mellitus and 40 aged matched apparently healthy control subjects on routine checkup. Malondialdehyde concentration was determined by spectrophotometric method. Serum c reactive protein was determined by enzyme-linked immunosorbent assay method. CD4+ T cells were estimated using Partec cyflow counter. There was a significant increase in MDA concentration, CRP and CD4+ T cells in type 2 diabetes mellitus subjects when compared with the aged matched control group (P < 0.05). Type 2 diabetes mellitus causes an increased production of free radicals which is possibly linked to the complications associated with non specific activation of CD4+ T cells.
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Keywords: Free radicals, CD4+ T cells, diabetes mellitus, cytokines, c reactive protein, malondialdehyde


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eISSN: 1997-342X
print ISSN: 1991-8631