Oral toxicity of trypanocidal molecules hemi-synthesized in Cymbopogon citratus essential oil
To ensure the safety of trypanocidal molecules of thiosemicarbazones hemi-synthesized in essential oil of Cymbopogon citratus, toxicology studies were conducted. These studies which were performed on rats “Wistar” had focused on our most active molecules: citral thiosemicarbazone, citral semicarbazone, citral 4-phenylthiosemicarbazone and the starting substrate which was the essential oil of Cymbopogon citratus. From these studies, it appears that citral semicarbazone, citral 4-phenylthiosemicarbazone and essential oil were no toxic as LD50 > 2000 mg/kg. Citral thiosemicarbazone was slightly more toxic with a LD50 = 315 mg/kg. The study of biochemical parameters revealed that the use of a high dose of the compounds may affect kidney function. A strong dose of essential oil of Cymbopogon citratus could affect liver function. It appears that the citral 4-phenylthiosemicarbazone is a very promising compound because it had an excellent antitrypanosomal activity and had very low toxicity (IC50 = 1.96 μM; LD50 > 2000 mg/kg).
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Keywords: Trypanocidal thiosemicarbazones, toxicology, essential oil, Cymbopogon citratus, biochemical parameters