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Evaluation of antiradical activity and acute toxicity of healing clays from Côte d’Ivoire
Abstract
Clays have been used since prehistoric times to treat various ailments around the world because of their many virtues including oxidative stress diseases. Several studies have shown the efficiency of natural antioxidants compounds in the treatment and prevention of oxidative stress diseases such as arterial hypertension, cancer, diabetesand rheumatism. This study aimed at checking if clays AK1 and AK2 used to treat various diseases in Ivory Coast possess an antiradical activity and are non-toxic. The antiradical activity was achieved by the DPPH free radical inhibition method. The two clays AK1 (IC50 =0.025 ± 0.0002 µg/mL) and AK2 (IC50 = 0.0423 ± 0.0001 µg/mL) showed antioxidant power; but the best value was that of AK1 whose antiradical activity was greater than that of the reference molecule Vitamin C (IC50 = 0.035 ± 0.0004 µg/mL). The study of their acute toxicity was carried out according to the OECD 423 method at limit dose of 5000 mg/kg of body weight. After fourteen days of observation, the results show that both clays are not toxic to rats, even in large doses (5000 mg/kg of body weight). Therefore, they could be used for effective therapeutic purposes.
